Lot RA-24118 • In Stock

MOTS-c, the mitochondrial-derived peptide for metabolic research.

A 16-amino-acid peptide encoded within mitochondrial DNA, acting as a mitohormone to influence metabolic processes.

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Research Specifications

Uncompromising Molecular Standards

99.8%

HPLC Purity

16

Amino Acid Chain

-20°C

Cold-Chain Ship

AMPK

Activator

Mechanism

Mimics exercise-induced metabolic adaptations.

MOTS-c activates AMP-activated protein kinase (AMPK), leading to enhanced glucose uptake and improved mitochondrial biogenesis.

Mitochondrial Peptide Research

Primary Research Applications

Investigating the physiological mechanism of MOTS-c across critical metabolic and cellular pathways in current pre-clinical research models.

Insulin Sensitivity

Enhances glucose uptake and activation of AMPK pathways, showing strong research outcomes in supporting systemic insulin action and cellular homeostasis.

Fat Oxidation

Promotes robust fatty acid breakdown and metabolic flexibility, supporting sustained energy cellular transitions and healthy lipid profiling.

Exercise Performance

Improves skeletal muscle endurance and reduces overall physiological fatigue, promoting healthy adaptation during metabolic and physical strain.

A single sequence, mitochondrial pathway.

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) represents a paradigm shift in molecular endocrinology. Unlike classical nuclear-encoded hormones, this mitochondrial-derived peptide (MDP) is transcribed directly from the mitochondrial genome, signaling an autonomous layer of cellular regulation that communicates directly with the nucleus.

Structurally defined as a highly conserved 16-amino-acid sequence, MOTS-c acts as an active metabolic orchestrator. Its primary physiological mechanism centers on the activation of the AMPK (AMP-activated protein kinase) pathway. By increasing cellular levels of AICAR, it promotes systemic glucose disposal, fatty acid oxidation, and adaptive cellular respiration.

As an investigational peptide, MOTS-c remains at the frontier of biogerontological and metabolic research. Current laboratory models focus on its capacity to restore metabolic homeostasis during age-associated decline, presenting a sophisticated, highly targeted candidate for future therapeutics aimed at cellular longevity and metabolic resilience.

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What the mitochondrial sequence is studied for.

Metabolic Signaling

Studied for its combined action across three incretin-related receptors.

Energy Expenditure Models

Referenced in research examining glucagon receptor engagement.

Energy Expenditure Models

Referenced in research examining glucagon receptor engagement.

DNA Line — Responsive Snippet

About The Compound

A single sequence, mitochondrial pathway.

MOTS-c is an investigational mitochondrial-derived peptide studied for its ability to regulate metabolic homeostasis. Each batch is sourced strictly for laboratory research—sealed under inert gas, freeze-dried for stability, and independently verified.

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VERIFIED QUALITY & RESULTS

What labs say after the first order.

"The consistency of the peptide batches has revolutionized our experimental timeline. Our mitochondrial respiration studies are finally yielding reproducible, publication-grade results."

Dr. Marcus Vance, Apex Mitochondrial Lab

"We switched to Motsc Premium after constant purity issues with other vendors. The biological activity we've observed in cellular viability and baseline ATP output was immediate and undeniable."

Dr. Elena Rostova, NeuroMetabolic Institute

"Unparalleled customer service paired with analytical grade research peptides. Every single shipment arrives with full HPLC and MS verification, which is absolutely vital for our workflow."

Dr. Julian Mercer, Vanguard BioLabs

RESEARCH & COMPLIANCE FAQ

Questions from the bench.

Is this sold for human use?

No. All products listed on this site are strictly for laboratory research, in vitro testing, and academic investigation. They are not intended, approved, or sold for human therapeutic, diagnostic, or clinical use under any circumstances.

What does the COA cover?

Each Certificate of Analysis (COA) confirms compound identity through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). It also details absolute purity levels (guaranteed above 98%) and verifies the complete absence of heavy metals or pyrogen contamination.

How should vials be stored?

Lyophilized peptide vials should be stored in a cool, dark location between 2°C and 8°C (36°F to 46°F) for short-term preservation. For long-term stability exceeding 3 months, we recommend storage at -20°C. Protect from direct light exposure.

Do you ship internationally?

Yes, we ship to certified research facilities worldwide. Please note that customs regulations vary significantly by destination country. The importing institution is fully responsible for ensuring compliance with all local laws and import clearances.

Quality & Purity Guaranteed

Get the next batch's COA before you order.

We transparently publish independent, third-party HPLC and Mass Spectrometry reports for every batch of MOTS-c. Verify 99.8%+ purity levels before completing your acquisition.

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